|
KMID : 0363620080290030001
|
|
Journal of Korean Oriental Medicine
2008 Volume.29 No. 3 p.1 ~ p.10
|
|
|
Bacterial Reverse Mutation Test of Sipjeondaebo-tang
|
|
Ma Jin-Yeul
Ha Hye-Kyung
Yu Young-Beob
Hwang Dae-Sun
Shin Hyun-Kyu
Lee Nam-Hun
|
|
|
Abstract
|
|
|
Objectives: This study was to assess the toxicity of Sipjeondaebo-tang by bacterial reverse mutation test.
Methods: In this study, to evaluate the bacterial reverse mutation of Sipjeondaebo-tang water-extract, the in vitro Ames test using Salmonella typhimurium (TA98, TA100, TA1,535, TA1,537) and Escherichia coli(WP2uvrA) were performed with Sipjeondaebo-tang water extract at the concentrations 0, 312, 625, 1250, 2500 and 5000 .
Results: Sipjeondaebo-tang water extract was negative in Ames test with both Salmonella typhimurium or Escherichia coli with and without rat liver microsomal enzyme (S9- fraction and S+ fraction).
Conclusions: According to these results, we concluded that a Sipjeondaebo-tang water extract did not cause bacterial reverse mutation.
|
|
|
KEYWORD
|
|
|
Sipjeondaebo-tang, reverse mutation, Ames test, Escherichia coli, Shiquan dabu-decoction
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|